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Stan Lee, the man who co-created Marvel Comics, has died ... Stan's daughter tells TMZ.

We're told an ambulance rushed to Lee's Hollywood Hills home early Monday morning and he was rushed to Cedars-Sinai Medical Center. We're told that's where he died.

Lee had suffered several illnesses over the last year or so -- he had a bout of pneumonia and vision issues.

Stan started Marvel with Jack Kirby in 1961 with The Fantastic Four. He went on to create Spider-Man, Black Panther, The Incredible Hulk, X-Men, Iron Man and The Avengers.

Stan made cameo appearances in all of the Marvel movies.