It seems to me that at this point in our brief developmental history we've barely scratched the surface of awareness about the universe, beginning with our own planet, the depths of which we've yet to explore. In other words, we don't even know what we don't know. Furthermore, knowledge itself--which can range from simple awareness to mastery--isn't static, as change occurs over time.

It is said that omniscience is the capacity to know everything, as opposed to the learning of it. If we assume it is possible that there could come a time--should our species or the artificial intelligence that we create continue to evolve in its capacity--when all that it known of cosmology, biology, mathematics, physics and disciplines yet to be discovered might inform us of what we've yet to learn, will there ever come a time when we have achieved unqualified mastery? In an infinite universe--or perhaps multiverse--it would seem unlikely, IMHO.

Thank you for this excellent thought exercise!