The sense of the world must lie outside the world. In the world everything is as it is and happens as it does happen. In it there is no value – and if there were, it would be of no value. If there is a value which is of value, it must lie outside all happening and being-so. (Ludwig Wittgenstein)
The meaning of the system lies outside the system. Therefore, the meaning of the universe lies outside the universe.
Science is not myth, myth is not science, but they are both explanations of some phenomenon within nature in terms of other phenomena within nature. In this sense, myth is proto-science. Science displaces myth. But neither yields meaning, since meaning is only provided by something (or someone!) outside the system: a transcendental order, be it real or imagined.
I kinda like where your going with this. I might fall back on the idea that my reality exists only in my mind. And each to his own, thus we all see a separate reality...one effectively imagined by us, only for us individually. I would put each of us observers outside of reality... we create reality by observing it. To observe, one mist typically be separate from. By that thought "the sense of the world must lie outside the world" may relate to consciousness instead of grand ideas, scientific principles, or patterns noticed in the larger universe.
There is no way for us to step outside reality to observe it, so to me this is a meaningless observation.
If Wittgenstein meant by "no value" that there is no externally bestowed meaning or purpose, then, well ... duh. However you and I are free to assign value / meaning / purpose for ourselves, to whatever we please.