"n one of the largest depression-related differences between the sexes, women have about twice the risk of developing the condition as men, Goldstein said. This results in part from biological reasons, such as hormones and genes that get disrupted when brain regions are developing in the male and female fetus, she said."

"These biological changes during fetal development lay the groundwork that creates a vulnerability to mood disorders, such as depression, she said.

In addition, women tend to be more tuned into their emotions, and better able to describe them when depressed, Goldstein said. Men might not recognize their symptoms as depression, perhaps denying or hiding their unhappiness, so the illness might get overlooked in men until it becomes more severe."

[livescience.com]