Captain Caveman and Scooby Doo, there is simply no competition. ???
I see some really good shows listed in the comments but no one has said Invader Zim.
"Why was there bacon in the soap?"
I have a vast array of animated shows that i greatly enjoy. So to ask me my favorite would probably give you different answers depending on which time you ask. At the moment the first one that comes to mind is the anime "Erased".
I love the science fiction / Supernatural aspect of it. There is also a time travel element was also very enjoyable and well-executed. It really spoke the sentiment we all have "if only I knew then what I know now".
Just yesterday I found out that someone who worked on Death Note, another one of my favorites, also worked on this one.
Bob's Burgers, Venture Bros, Archer, Daria, Futurama, American Dad, Family Guy, Ugly Americans, the Critic, the Simpsons, Seven Deadly Sins, Spice and Wolf, the Devil is A Part Timer, Soul Eater, Deadman Wonderland, Blue Exorcist, Fruits Basket, Attack on Titan, Assassination Classroom, Hellgirl, FLCL, Xxxholic, Death Parade, Durarara, Ranma 1/2
Both Vampire Hunter D's, Fatal Fury the Motion Picture, Akira, Iria, Flight of Dragons, Boy and the Beast, Wizards, Castle of Cagliostro...
I'm sure I'm forgetting a bunch.
There are lots of good, adult-themed cartoons these days. A few I really like are:
There's a wonderful video by the YouTube channel wisecrack about the philosophy of Rick and Morty and BoJack Horseman. It explores the forms of nihilism in both serieses. He cites many philosophers to support his analysis. I really enjoyed it if you haven't seen it I recommend you check it out.
Not in order:
Violet Evergarden
Cowboy Beebop
Steamboy
Fullmetal Alchemist
Samurai Champloo
From up on Poppy Hill
Bob's Burgers
Grave of the Fireflies
Aqua Teen Hunger Force
Appleseed
Fooly Cooly
Attack on Titan
Ghost in the Shell
Robot Chicken
Morel Orel
...more I can't think of right now. Christ! I watch more cartoons now than when I was 10 yo. Some are just wonderful stories...better than most of the junk on TV.
Bugs Bunny all the way, man. The king!
?? or any of the old Loony Toons ?