Hmm! Freud was addicted to cocaine and as a physician he had free and easy access to it. As for mystical experience I'm sure everyone has heard or read the words of someone who said, 'I had a great trip! It was a gas!' The tripper brought nothing back with him, no great insights, answers to conundrums nor explanations of mysteries, usually incoherent babble.
The only one that I recall who did was Coldridge, who produced Xanadu. But I think that he may have been deluding himself, if not others, a bit. To compare it to the advent of literacy in human history, is just silly.
Of the three pyschotechnologies listed I'd posit getting off your nut is as nothing compared with literacy and numeracy which tells you where, when, why and how you find the nuts.
How literacy and numeracy changed humanity forever and how psychotropic mind alteration can lead to fun and profit.
This piece sounds lovely but ignores facts.......
You are being very kind.